2026, Vol. 8, Issue 1, Part B

Objective: To examine the pharmacological research on Aegle folia and assess its potential therapeutic relevance in homeopathy.

Methods: Following the PRISMA 2020 guidelines, an extensive search was carried out in databases such as Scopus, PubMed, Web of Science, and Google Scholar. Studies published from 2005 onward that explored the therapeutic roles and pharmacological characteristics of Aegle folia were included.

Results: The review highlights that Aegle folia exhibits a broad range of pharmacological effects, including antidiabetic, hepatoprotective, neuroprotective, antioxidant, and antiseptic activities, along with other health-promoting benefits. Bioactive constituents such as flavonoids, coumarins, alkaloids, and polyphenols contribute to these actions. Its traditional use aligns with several homeopathic indications, yet lacks systematic provings and standardization.

Conclusion: Aegle folia hold promise for integration into homoeopathy. However, further clinical validation and standardized provings are required to define its role in the Materia medica. Interdisciplinary studies combining pharmacology and homeopathy are recommended.