Autism Spectrum Disorder (ASD), as defined by ICD-11, involves persistent deficits in social communication and interaction, along with restricted and repetitive behaviours. Although early signs may appear in infancy, ASD is often identified only when social milestones are delayed. In India, its prevalence is estimated at 1-1.5%, with a male predominance. Emerging research highlights prenatal and periconceptional stress as significant risk factors. Maternal stress activates the Psycho-Neuro-Endocrine-Immuno (PNEI) axis, increasing cortisol and catecholamines, which can impair placental function and fetal neurodevelopment. Paternal stress may induce epigenetic changes in sperm DNA, influencing susceptibility to ASD.
In Homoeopathy, the principle of Tolle causam emphasizes identifying dynamic causes underlying disease. Exploring the emotional and perceptual state of parents—particularly the mother—during pregnancy helps understand the origins of impaired communication seen in ASD. Integrating such psychological insights with individualized homoeopathic case-taking may support more precise remedy selection and deeper therapeutic outcomes.