2024, Vol. 6, Issue 1, Part A

This review explores recent advancements in Lewis acid catalysis for Friedel-Crafts acylation reactions, highlighting innovative catalyst designs, enhanced reaction efficiencies, and the expansion of substrate scope. Lewis acid catalysts play a pivotal role in facilitating acylation reactions by activating acyl chlorides and carbonyl compounds towards nucleophilic attack. The evolution of catalytic systems, including the use of environmentally benign and recyclable materials, has significantly contributed to the development of more sustainable and efficient synthetic pathways for aromatic ketone production. This paper synthesizes the current state of knowledge, discusses the mechanistic insights gained from recent studies, and outlines the future direction of research in this field.