International Journal of Advanced Academic Studies
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International Journal of Advanced Academic Studies

2019, Vol. 1, Issue 1, Part A

Cytotoxicity studies and spectral description on Cr(III), Ru(III), Mn(II), Ni(II), Cu(II), Zn(II) and Co(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde


Author(s): Dr. Sharad Kumar Jha

Abstract: Coordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. Elemental analytical data, IR, NMR (1H, 13C and 15N), EPR, XRD, SEM, TEM, EDX, TGA, mass, molar conductance, magnetic moment, and UV-Visible spectra techniques were used to confirm the structure of the synthesized chelates. According to the data obtained, the composition of the 1: 1 metal ions: furan Schiff base ligand was found to be [M(MFMAQ)Cl2] (M = Cr(III) and Ru(III)) and [M(MFMAQ)Cl(H2O)]. nH2O in which (M =Mn(II); n=1, Co(II); n=0, Ni(II); n = 2, Cu(II); n= 0 and Zn(II); n = 2.5). The measurements of magnetic susceptibility, ligand field parameter, and reflectance spectra suggested an octahedral geometry for the complexes. Central metals ions and furan Schiff base coordinated via O3 and N donor sites which was observed from IR spectra. The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.

Pages: 145-157 | Views: 77 | Downloads: 39

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How to cite this article:
Dr. Sharad Kumar Jha. Cytotoxicity studies and spectral description on Cr(III), Ru(III), Mn(II), Ni(II), Cu(II), Zn(II) and Co(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde. Int J Adv Acad Stud 2019;1(1):145-157.
International Journal of Advanced Academic Studies